Pair Name	Ginsenoside Rg3, Tamoxifen
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Glycolysis
Gene Regulation	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	PFKFB3	hsa5209
	Down-regulation	Expression	PFKM	hsa5213
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	T-47D	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0553
	HEK293T	Healthy	Homo sapiens (Human)	CVCL_0063
In Vivo Model	A total of 6×10⁶ cells were suspended in 100 μL of a 1:1 mixture of Matrigel and phosphate-buffered saline (PBS),and then injected into the flanks of nude mice.
Result	This study highlights the contribution of Rg3 in enhancing the therapeutic efficacy of TAM in breast cancer, and suggests that targeting TAM-resistant PFKFB3 overexpression may represent a promising strategy to improve the response to combination therapy in breast cancer.